I posted an article a little while ago that explains the basics of what everyone is talking about. If you PM me ill send it to you.
So far in this thread, the conversation is excellent and the posters really know their stuff. I'll just add my 2 cents.
If you have some bad ju ju in your tank, way better to replace water than add more and more things into the water which gets expensive and puts more and more stress on the fish due to the principle of osmosis. Which very loosely defined=water will flow from an area of high concentration to an area of low concentration. If you are adding more and more other things into the water, like salt and chemicals and whatever else, there will be more pressure on the fish to deal with the change in the balance of power the water molecules are putting on them. It it gets bad enough, the fish will stress out quickly and fall victim more easily to the various terminal illnesses.
The one thing that can really help out any problem in any setting is water changes with dechlorinated water. It also helps to keep the fish in water that has similar hardness.
For example if you filled up your tank with tap water and the fish are used to the hardness of your water, doing a large water change with distilled water could stress your fish. The fastest way to turn a tank from super lethal to livable is a LARGE water change (60% is the most I would ever go at a time). Do the changes often at first. If you want to change out all the water in your tank, the smaller amount you remove at a time the longer it takes to replace the water. If you take out say 20% of the water in a change every two days, it will take you 20 days to remove 90% of the bad water.
Here is a little graph I made discussing this point.
In a 400 gallon system large water changes can be a pain. In my experience, they really are a better cure than trying to diagnose a specific water quality issue and then adding all kinds of treatments to your water to counteract the bad stuff in there. I used to do this and I would misdiagnose things and make the problems worse.
When you do water changes please, for the love of Pete, do not clean your filters out with chlorinated water or do anything to the living bacteria colonies that will reduce their numbers. Scrubbing the crap out of the sides/bottom of your tank or letting the tank dry out or forgetting to feed the system while there are no fish in it are a few surefire ways to set yourself up for heartache. You are going to need healthy bacteria to keep healthy bait.
Oh, I forgot, on the feeding topic. Feeding the fish any more often than every 3 days is a no no with wild fish and even store bought fish only need it every 2 or so if that.